Environmental Project's Achievements Reports Query System

Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan (II)

Absrtact	The project entitled “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan Part II.” is a continuous project of a three-year research project entitled “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan.” and “Asian Continental Dust Storm -Induced Health Effects in Taiwan.” In the project of “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan.” we establish a Supersite and a “Particle toxicological laboratory”. In the project of “Asian Continental Dust Storm-Induced Health Effects in Taiwan.” we establish “Surveillance net of emergency case” and “Surveillance net of susceptible population” to evaluate the relationship between dust storm and subjects. By applying these critical research techniques to particle researches, we have achieved the following four specific research objectives. First, the Supersite monitoring during 1/1/2003-10/31/2002 have provided new and detailed size-specific number and mass PM concentration. Significantly high PM10, PM2.5, total carbon, organic carbon, and nitrate concentrations have been observed during the morning and afternoon commute periods. Second, concentrated ambient particles in Shin-Chuan City of Taipei County didn’t show any significant cardio-circulatory toxicity on diseased rat models. Such results were due to the effects of transportation for disease rats from Laboratory Animal Center to Shin-Chuan City. Third, PM collected from different pollution sources induced different levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) released from BEAS-2B cells. PM from straw and Chinese incense has greater cellular toxicity than PM from tobacco. Forth, we found decreases in IL-6 t-PA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor-1) among patients with coronary artery disease during the dust storm period in 2003. We also found an increase in fibrinogen and a decrease in log10pNN50 (percent of adjacent NN intervals differing by more than 50ms) among patients with diabetes during the dust storm period.
Keyword	air pollution,particle,supersite,risk assessment

Absrtact

The project entitled “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan Part II.” is a continuous project of a three-year research project entitled “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan.” and “Asian Continental Dust Storm -Induced Health Effects in Taiwan.” In the project of “Health Risk Assessment on Ambient Air Pollution of Particles in Taiwan.” we establish a Supersite and a “Particle toxicological laboratory”. In the project of “Asian Continental Dust Storm-Induced Health Effects in Taiwan.” we establish “Surveillance net of emergency case” and “Surveillance net of susceptible population” to evaluate the relationship between dust storm and subjects. By applying these critical research techniques to particle researches, we have achieved the following four specific research objectives. First, the Supersite monitoring during 1/1/2003-10/31/2002 have provided new and detailed size-specific number and mass PM concentration. Significantly high PM10, PM2.5, total carbon, organic carbon, and nitrate concentrations have been observed during the morning and afternoon commute periods. Second, concentrated ambient particles in Shin-Chuan City of Taipei County didn’t show any significant cardio-circulatory toxicity on diseased rat models. Such results were due to the effects of transportation for disease rats from Laboratory Animal Center to Shin-Chuan City. Third, PM collected from different pollution sources induced different levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) released from BEAS-2B cells. PM from straw and Chinese incense has greater cellular toxicity than PM from tobacco. Forth, we found decreases in IL-6 t-PA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor-1) among patients with coronary artery disease during the dust storm period in 2003. We also found an increase in fibrinogen and a decrease in log10pNN50 (percent of adjacent NN intervals differing by more than 50ms) among patients with diabetes during the dust storm period.

Keyword

air pollution,particle,supersite,risk assessment